Magnesium Treatment for Drug-Induced QT Prolongation

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Drug induced QT prolongation.

The drug-induced QT prolongation predisposes to development of torsades de pointes (TdP) ventricular tachycardia and sudden death. The association between specific drug and development of TdP is difficult to document, therefore, QT prolongation is considered as a surrogate marker of the proarrhythmia risk. Most of the drugs prolong QT interval usually by blocking the potassium IKr current or al...

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Drug-Induced Prolongation of the QT Interval

N Engl J Med 2004;350:1013-22. Copyright © 2004 Massachusetts Medical Society. n the past decade, the single most common cause of the withdrawal or restriction of the use of drugs that have already been marketed has been the prolongation of the QT interval associated with polymorphic ventricular tachycardia, or torsade de pointes (Fig. 1), which can be fatal. 1 Nine structurally unrelated drugs...

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Drug-induced prolongation of the QT interval.

N Engl J Med 2004;350:1013-22. Copyright © 2004 Massachusetts Medical Society. n the past decade, the single most common cause of the withdrawal or restriction of the use of drugs that have already been marketed has been the prolongation of the QT interval associated with polymorphic ventricular tachycardia, or torsade de pointes (Fig. 1), which can be fatal. 1 Nine structurally unrelated drugs...

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Drug-induced QT prolongation journal article

Background: Although QT prolongation is associated with increased risk of torsade de pointes (TdP), the precise relationship is not well defined. Aim: To evaluate the performance of a QT nomogram in assessing the risk of TdP from QT– RR combinations. Design: Systematic review. Methods: We systematically searched MEDLINE/ EMBASE for cases of drug-induced TdP. Controls were patients taking non-ca...

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Drug-Induced QT Prolongation And Torsades de Pointes.

Torsades de pointes (TdP)-an uncommon but life-threatening polymorphic ventricular tachycardia-is almost always drug induced. The authors describe the causes, risk factors, symptoms, diagnosis, and treatment of TdP.

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ژورنال

عنوان ژورنال: Journal of Arrhythmia

سال: 2011

ISSN: 1880-4276,1883-2148

DOI: 10.4020/jhrs.27.pj2_043